Interestingly, TET2 inhibits the PD-L1 expression independently of its catalytic activity, and TET2 recruits Histone Deacetylase (HDAC) 1/2 to PD-L1 promoter to deacetylate H3K27ac in MCF-7 and MDA-MB-231 BC cells [80]. The gene discussed is CD274; the disease is breast cancer.