KMT2A and acute myeloid leukemia: As shown in Figure 1, in 2002, a genetic alteration in the TET1 gene was identified through the detection of a chromosomal rearrangement, specifically the translocation 10q22-11q23 of TET1 and Lysine Methyltransferase 2A (MLL1) genes in acute myeloid leukemias [12,13].