The miR-27a-3p down-regulates TET1 expression, which inhibits the Adenylyl Cyclase type 6 (ADCY6) expression by aberrant methylation in its promoter, promoting the cell proliferation, migration, and invasion in MCF-7 and MDA-MB-231 BC cells, while TET1 re-expression rescues these effects [69]. This evidence concerns the gene TET1 and breast cancer.