Among protein-coding genes located between BP4 and 5, five genes, including TAOK2 (a pLI score of 1.00), CORO1A (0.97), MAZ (0.93), PAGR1 (0.74), and PRRT2 (0.59), have a pLI value of 0.5 or more and are associated with symptoms related to 16p11.2 deficits and are implicated in genetic disease. Here, TAOK2 is linked to hereditary disease.