Evidence from animal studies demonstrated the therapeutical action of resveratrol in T2D using different mechanisms such as improvement of insulin action in animals with experimentally induced insulin resistance [28,29,30] and enhancing the insulin signaling pathway in the liver of insulin-resistant animals through the phosphorylation of several signaling proteins, including IRS-1, Akt and PI3K [31,32]. Here, INS is linked to type 2 diabetes mellitus.