KLK3 and neoplasm: In further delving into the nuances of this correlation, the application of multivariate Cox regression models unearthed a significant finding: the compromised treatment outcomes observed in individuals with augmented 28S rRF levels stand as an autonomous factor, independent of a spectrum of clinicopathological variables encompassing tumor stage, GS, PSA levels, outcomes of DRE, and even patients’ chronological age.