CD8A and neoplasm: Anticancer cells, such as Natural Killer (NK) cells and CD8+ T lymphocytes, can recognize and eliminate tumor cells; on the other side, immunosuppressive cells, such as regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs), can support the evasion of immune surveillance by neoplastic cells and promote tumor growth [2].