TIGIT and neoplasm: Then, we evaluated whether the treatment with CUR and RES could affect the expression of molecules involved in the recognition of tumor target cells by NK cells, including activating receptors (NKG2D, DNAM-1, NKp30 and NKp46), inhibitory receptors (NKG2A, KIRs) and exhaustion receptors (PD-1 and TIGIT) [74].