EGFR and neoplasm: Tumor mutational burden (TMB) did not statistically differ between the two subgroups (p = 0.18), but the most common molecular alterations found in the two cohorts were different: for instance, higher prevalence of EGFR mutations (30% vs. 0%) was found in never/ever smokers, whereas a greater frequency of RB1 mutations (80% vs. 40%) was detected in patients with smoking history [9].