In addition, to support the universality of the BIRC5 knockdown effect in all RCC cells, the BIRC5 knockdown effect was also confirmed by evaluating BIRC5 mRNA levels in the second ccRCC cell line Caki-2 and the second pRCC cell line A498 (Supplementary Figure S1). The gene discussed is BIRC5; the disease is nonpapillary renal cell carcinoma.