In this sense, it is exciting to recognize that meta-analysis was carried out by van Rhijn et al. who had written one of the first extensive literature reviews for the use of 18 markers and concluded that MSA, ImmunoCyt, NMP22, CYFRA21-1, LewisX, and FISH are the most promising markers for surveillance [67,69,70,71,72,73,74,75,76,77] of early detection for bladder cancer. This evidence concerns the gene NUMA1 and urinary bladder cancer.