TP53 and breast cancer: Several germline mutations that increase the risk of developing BC have been identified in genes such as BReast CAncer genes 1 and 2 (BRCA1/2), Tumor protein p53 (TP53), Partner and Localizer of BRCA2 (PALB2), phosphatase and tensin homolog (PTEN) and mutated ataxia-telangiectasia (ATM) [8].