At last, genetic factors including mutations in genes involved in DNA repair pathways—like the Fanconi anemia (FA)/BRCA pathway, active during the repair of ICLs—or mutations in genes associated with premature ovarian insufficiency (POI)—of which Fragile X Messenger Ribonucleoprotein 1 (FMR1)—can lead to premature ovarian ageing [63,64]. This evidence concerns the gene FMR1 and Premature ovarian insufficiency.