BRCA1 and cancer: It has also been demonstrated that BRCA1 plays a role in cancer stem cells’ (CSC) development and evolution by regulating several signaling pathways such as phosphatidylinositol-4,5-bisphosphate-3-kinase (PI3K)/protein kinase B (AKT), Hedgehog, Janus kinase (JAK)—Signal Transducer and Activator of Transcription proteins (STAT) and Notch [21].