The theory that cytokines in UC IL-22, IL-17 (Th17, ILC3), IL-22 (Th17, Th22), and IL-9 (Th-9) under pathological conditions (e.g., IBD) may cause epithelial inflammation due to endoplasmic reticulum (ER) stress response is worth further investigation [207,208]. This evidence concerns the gene IL22 and inflammatory bowel disease.