On the mRNA level, more than 50 overexpressed genes were reported in MM that could serve as diagnostic, predictive, or prognostic markers, or even therapeutic targets, including MSLN, encoding for mesothelin, EFEMP1, encoding for fibulin 3, BIRC5, encoding for survivin and CALB2, encoding for calretinin [11]. This evidence concerns the gene EFEMP1 and Miyoshi myopathy.