For example, circSMARCA5 in breast cancer has binding sites on its parental gene and, upon binding, forms an R-loop that pauses transcription at exon 15 of SMARCA5, a member of the SWI/SNF complex with ATP-dependent chromatin remodeling activity, resulting in decreased expression of SMARCA5 and the production of truncated non-functional protein [27]. Here, SMARCA5 is linked to breast cancer.