The results of PPI analysis confirm the interaction between CAC pathways, including the inflammasome pathway (NLRP3, NOS2, SIRT1, TLR4, STAT3, IGFB3), adipogenesis and insulin resistance (PPARG, GSK3B), pathogenic signaling (SERPINE1), cell cycle and apoptosis (SIRT1, TNF), and tissue remodeling (PLG, MMP9) [76]. The gene discussed is NOS2; the disease is Insulin resistance.