The results of PPI analysis confirm the interaction between CAC pathways, including the inflammasome pathway (NLRP3, NOS2, SIRT1, TLR4, STAT3, IGFB3), adipogenesis and insulin resistance (PPARG, GSK3B), pathogenic signaling (SERPINE1), cell cycle and apoptosis (SIRT1, TNF), and tissue remodeling (PLG, MMP9) [76]. The gene discussed is TNF; the disease is Insulin resistance.