NFKB1 and colorectal carcinoma: Future endeavors may focus on utilizing CRC models (e.g., PDX or organoids, or isogenic human embryonic stem cell (hESC)-derived colonic cells, or human pluripotent stem cells (hPSC)-derived colonic organoids, etc.)to further uncover the underpinning mechanism of these genetic alterations in NF-κB signaling in CRC progression.