Recently, using the powerful validation-based insertional mutagenesis (VBIM) technique established by our laboratory previously [39,44], we discovered outer dynein arm docking complex subunit 2 (ODAD2) (also named armadillo repeat-containing protein 4 (ARMC4), a rarely studied protein known to date, as a novel negative regulator of NF-κB in CRC. This evidence concerns the gene NFKB1 and colorectal carcinoma.