TYR and hydrops fetalis: The treatments with the COE and its fractions decreased the tyrosinase activity (COE, 280.52 ± 3.28%; HF, 233.15 ± 41.40%; CF, 171.05 ± 9.51%; EF, 243.94 ± 8.24%, BF, 275.00 ± 4.62%; WF, 297.89 ± 7.94%) and kojic acid (226.31 ± 3.97%).