Enrichments included the following: untreated vs. tgfb il6 treated cd4 tcell up, resting vs. tcr activated cd4 tcell up, bm vs. colon tumor myeloid-derived suppressor cell dn, flt3l induced dec205 pos dc vs. cd4 tcell dn, unstim vs. anti igm stim tak1 ko bcell 3h dn, wt vs. klf13 ko thymic-memory-like cd8 tcell dn, and marginal zone bcell vs. memory bcell day7 dn, especially the low-IRPM group (Figure 10F), which suggests that IRPM score was closely associated with the TME and tumor progression in PAAD. This evidence concerns the gene TGFB1 and neoplasm.