Furthermore, epithelial cells in the low-IRPM group had a high number of interacting pairs with Monocyte, Tissue_stem_cells, endothelial cells, NK_cell, and T_cells, especially for SPP1_CD44, ITGAV_ITGB5, ITGAV_ITGB1, ITGA4_ITGB1, ITGA5_ITGB1, ITGA6_ITGB1, and NAMPT_INSR (Figure 10E), which are known to promote tumor growth, invasion, and metastasis. The gene discussed is INSR; the disease is neoplasm.