In this regard, it has been described in a model of tuberculosis using epithelial cells that IL-17 can regulate MMP-3 expression, secretion, and activity, since this cytokine exerts a cooperative and synergistic effect by stabilizing the mRNA of other inflammatory cytokines that are related to the secretion of MMP-3 and its possible activators [31]. The gene discussed is IL17A; the disease is tuberculosis.