According to the results of the study, it was concluded that the presence of a triple complex allele p.[Asp443Tyr;Gly576Ala;Arg668Cys] is accompanied by a decrease in CFTR function and is responsible for the occurrence of CFTR-related disorders (CFTR-RD: bronchiectasis, chronic sinusitis, idiopathic pancreatitis, cholestasis, and congenital bilateral absence of vas deferens (CBAVD)) [27]. The gene discussed is CFTR; the disease is chronic rhinosinusitis.