Interestingly, the p53/p66Shc pathway could play a role in regulating the progression of NASH, since the p53 knockout suppressed p66Shc signaling and, at the same time, it decreased hepatic lipid peroxidation and the number of apoptotic hepatocytes and ameliorated the progression of nutritional steatohepatitis [84]. Here, TP53 is linked to metabolic dysfunction-associated steatohepatitis.