VDR and Mycobacterium infection: A pilot study by Yang et al. identified an inverse correlation between the VDR hypermethylation pattern and the expression level of VDR, IL-1β, IL-6, and TNF-α genes in RAW 264.7 cells previously infected with Mycobacterium, suggesting a protective effect of the VDR hypomethylation signature against Mycobacterium infection [52].