SMARCA4 and small cell lung carcinoma: Genes encoding chromatin modifying complexes (e.g., BAF-SWI/SNF and PBAF-SWI/SNF complexes) have been identified as being frequently mutated in SCLC, including the ARID1A/B (AT-rich Interaction Domain 1A and 1B), BRG1 (or SMARCA4), PBRM1 (Polybromo-1), and CHD7 (Chromodomain Helicase DNA Binding Protein 7) genes [14].