Moreover, the analysis of the localization of p-p38 showed the greatest increase in the immunoreactivity of this kinase in the glomerular layer and medulla of rats with primary hypertension and in the glomerular layer of rats with secondary hypertension, which may suggest a different hormonal function of adrenal cells depending on the etiology of hypertension. The gene discussed is MAPK14; the disease is secondary hypertension.