The interaction of CacyBP/SIP with ERK1/2 and p38 by regulating the activity and intracellular localization of these kinases, perhaps play an important role in the signaling pathways related to the sympathetic nervous system or the renin angiotensin aldosterone system, which are involved in the pathogenesis of hypertension. The gene discussed is MAPK1; the disease is hypertensive disorder.