In search of new mechanisms involved in the pathogenesis of hypertension, this research is a pilot study and an introduction to the assessment of a certain functional relationship of CacyBP/SIP with ERK1/2 and p38 kinases in the adrenal glands of hypertensive rats, which may contribute to broadening our knowledge on the interaction of CacyBP/SIP protein with MAP kinases. The gene discussed is MAPK3; the disease is hypertensive disorder.