Since arterial hypertension is accompanied by both abnormal secretion of mineralocorticoids, responsible for the regulation of water and mineral balance, and catecholamines, affecting the functioning of the cardiovascular system, we tracked the localization and expression of the CacyBP/SIP protein and kinases ERK1/2 and p38 in the adrenal cortex and medulla, which have different origins, structures and endocrine functions. Here, MAPK3 is linked to Hypertension.