KEGG pathway analysis showed upregulation of the term “ECM-receptor interaction”, which includes integrin subunit alpha 3 (ITGA3), collagen type VI α1 chain (COL6A1), and heparan sulfate proteoglycan 2 (HSPG2) in the non-emphysema subgroup. The gene discussed is COL6A1; the disease is pulmonary emphysema.