CXCL1 and psoriasis: However, some familial psoriasis cases suggest abnormal cell signaling and transcription responses in keratinocytes may lead to psoriasis in genetically susceptible populations, and keratinocytes produce neutrophil chemotactic factors in psoriasis inflammation, such as chemokine (C-X-C motif) ligand 1 (CXCL1) and chemokine (C-X-C motif) ligand 2 (CXCL2) [57].