SETD2 and neoplasm: Under the condition of the tumor microenvironment and tumor-similar macrophages, the high expression of VEGF and ARG1 by up-regulated HIF-1 α and lactic-acid-mediated HIF-1 α is stable under constant upstream oxygen material so as to activate VEGF and ARG1, which eventually results in tumor-associated macrophage (TAM) to M2 type polarization, and ARG1 secreted by TAM2 promotes tumor growth [54].