Accumulative evidence suggests that polyphenols are essential in preventing and managing T2D via two approaches: (1) The insulin-dependent approaches; this involves the pancreatic islet β-cell protection from hyperglycemia-induced oxidative stress [18,19], promotion of β-cell proliferation [20], activation of insulin signalling [21], and stimulation of pancreatic insulin secretion [22]. Here, INS is linked to type 2 diabetes mellitus.