2.1. Vinorelbine Demonstrated Antimitotic and Apoptotic Activities, Reduced Tumor Hypoxia via Blood-Vessel Normalization, and Upregulated Downstream Targets (p-p70S6K/4EBP1/Survivin) of the mTOR Pathway in HCC PDX Models. The gene discussed is MTOR; the disease is hepatocellular carcinoma.