It also significantly increased the numbers of both total blood vessels and productive blood vessels while mitigating tumor hypoxia in the mTOR-sensitive HCC25–0705A and HCC24–0309 PDX models (Supplementary Figures S5, S6, S12 and S13) but not in the vinorelbine-sensitive HCC19–0913, HCC13–0109, and HCC13–0212 PDX models (Figure 2 and Supplementary Figures S5, S6, S11 and S12). Here, MTOR is linked to neoplasm.