Experiments in which GL261-Luc glioblastoma cells were implanted in both wild-type and p50 knockout (ko) mice resulted in extended survival in the ko mice, characterized by a shift in TAM populations towards pro-inflammatory M1 markers and a threefold increase in tumor-associated CD4 T cells compared to wild-type mice [29]. The gene discussed is NFKB1; the disease is neoplasm.