It was reported that in two model ABC DLBCL cell lines with mutated CD79B, PI3K signaling and downstream PDK1 (putative 3-phosphoinositide-dependent kinase 1) activation are essential events for CARD11-BCL10-MALT1 signalosome complex-mediated NF-κB activation [159]. The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.