The MCD (combined MYD88L265P and CD79B mutations), N1 (mutated NOTCH1), and A53 (aneuploid and TP53 inactivation) subtypes are significantly overlapping with the ABC DLBCL subtype, whereas EZB (mutated EZH2 and translocated BCL2), ST2 (mutated SGK1 and TET2), and BN2 (translocated BCL6 and mutated NOTCH2) are overlapping with GCB DLBCL [56]. The gene discussed is EZH2; the disease is diffuse large B-cell lymphoma.