CD4 and cancer: Indeed, a pan-cancer analysis based on the data from GTEx and TCGA shows that, in cervical squamous cell carcinoma and endocervical adenocarcinoma patients, the expression of S1PR2 is markedly positively related to immune cells such as the dendritic cell, neutrophil, CD4+ T cell, and macrophage, as well as B cell, and patients with a lower S1PR2 expression have a worse prognosis [185].