Commensurate reductions in FXR and CDX2 resulting from inactivating APC mutations are observed in the tumor tissues of Apcmin/+ mice and familial adenomatous polyposis (FAP) patients, indicating that mutations in CRC-related genes also contribute to intestinal FXR gene silencing [107]. The gene discussed is NR1H4; the disease is Familial adenomatous polyposis.