In sepsis-induced pediatric AKI, RSV was observed to palliate sepsis-induced injury by inducing the activation of the Nrf2 signaling pathway, leading to its dissociation from Keap1 and binding to the antioxidant response element (ARE) within the promoter of its downstream genes, including uridine 5′-diphosphate-glucuronosyltransferase, NAD(P)H: quinone oxidoreductase-1 (NQO1), HO-1, glutamate cysteine ligase, glutathione S-transferase, and GPx. This evidence concerns the gene HMOX1 and Sepsis.