Meanwhile, the percentages of CD4+CCR7+CCR6+ cmTh17 (Figure 2D) and CD4+CCR7−CCR6+ emTh17 (Figure 2E) cells were significantly lower in the DSS+APS group than in the DSS group, while CD4+CCR7+Foxp3+ cmTreg (Figure 3D) and CD4+CCR7−Foxp3+ emTreg cells (Figure 3E) were significantly higher. The gene discussed is CD4; the disease is autoimmune polyendocrinopathy.