Critically, the colitis mice also exhibited an abnormal imbalance of mTh17/mTreg cells with higher frequencies of CD4+CCR7+CCR6+ cmTh17 (Figure 2D) and CD4+CCR7−CCR6+ emTh17 cells (Figure 2E) and lower frequencies of CD4+CCR7+Foxp3+ cmTreg (Figure 3D) and CD4+CCR7−Foxp3+ emTreg cells (Figure 3E) in the MLNs. This evidence concerns the gene FOXP3 and colitis.