Importantly, APS reversed the expression changes in the TIGIT molecule on mTh17/mTreg cells in the colitis mice with fewer CD4+CCR6+TIGIT+, CD4+CCR7−CCR6+TIGIT+ and CD4+CCR7−CCR6+TIGIT+ cells and more CD4+Foxp3+TIGIT+, CD4+CCR7−Foxp3+TIGIT+ and CD4+CCR7−Foxp3+TIGIT+ cells. The gene discussed is CD4; the disease is colitis.