At the same time, CD4+CCR6+TIGIT+ (Figure 4D), CD4+CCR7−CCR6+TIGIT+ (Figure 4E) and CD4+CCR7−CCR6+TIGIT+ (Figure 4F) cells in MLNs were significantly higher in the DSS+APS group than in the DSS group, while CD4+Foxp3+TIGIT+ (Figure 5D), CD4+CCR7+Foxp3+TIGIT+ (Figure 5E) and CD4+CCR7−Foxp3+TIGIT+ (Figure 5F) cells were significantly lower. This evidence concerns the gene CCR7 and autoimmune polyendocrinopathy.