Here, we found that the levels of CD155 (Figure 6A,B), CD113 (Figure 6A,C) and CD112 (Figure 6A,D) proteins were significantly higher in the colonic tissues of the colitis mice in the DSS group than in the Ctrl group, the mRNA levels of CD155 (Figure 6E) and TIGIT (Figure 6F) were also significantly higher, and a stronger CD155-positive signal in the tissue of the lamina propria was observed under fluorescence microscopy (Figure 6G). This evidence concerns the gene NECTIN2 and colitis.