Currently, Grb14 is believed to play a critical role in regulating insulin signaling and glucose homeostasis: (i) Grb14 knock-out mice (Grb14−/−) exhibited improved glucose tolerance, albeit lower circulating insulin levels [11]; (ii) Grb14 mRNA levels were found to be increased in adipose tissue of ob/ob, T2DM model mice [12]; (iii) genome-wide association studies for the South Asian region demonstrated a relevance of Grb14 to metabolic disorders, especially insulin resistance [13]. This evidence concerns the gene INS and metabolic disease.