SLC6A3 and Parkinson disease: OLDA modulated the firing of nigrostriatal DA neurons by interacting with TRPV1 and blocking the dopamine uptake (dopamine transporter, DAT) and dopamine 2 receptor (D2R) activation, then leading to a wake-on-firing pattern of histaminergic (HA) neurons, suggesting the beneficial role of OLDA in PD [91,130] (Figure 4b).