YTHDF1 collaborates with YTHDF3 to specifically recognize TGFβR2 (TGF-β receptor 2) and SMAD3 (SMAD Family Member 3) mRNA, thereby facilitating the promotion of TGF-β-induced epithelial–mesenchymal transition (EMT) leading to NSCLC progression. Here, SMAD3 is linked to non-small cell lung carcinoma.