YTHDF1 functions as an m6A-dependent mediator in NSCLC, facilitating METTL3-mediated methylation modification of FRAS1 (Fraser extracellular matrix complex subunit 1) mRNA, thereby regulating the expression of CDON (cell adhesion-associated, oncogene-regulated). This evidence concerns the gene METTL3 and non-small cell lung carcinoma.