TGFB1 and Hepatic fibrosis: Dietary polyphenols have anti-inflammatory and antioxidant properties, and they have been reported to inhibit TGF-β/Smad, Wnt/β-catenin, NF-κB, PI3K/AKT/mTOR, hedgehog pathway, or activate the AMPK/mTOR pathway to reverse liver fibrosis.