Dietary polyphenols are used in the treatment of liver fibrosis and act through multiple pathways, such as TGF-β/Smad, AMPK/mTOR, Wnt/β-catenin, NF-κB, PI3K/AKT/mTOR, hedgehog pathways and liver fibrosis-related factors. Here, PRKAA1 is linked to Hepatic fibrosis.