TNF and obesity due to melanocortin 4 receptor deficiency: Obesity is characterized by a state of chronic, low-grade inflammation, which may act as the potential link between adipose tissue expansion and obesity-induced health complications, as the adipose tissue is an active endocrine organ that is capable of producing cytokines and adipokines like tumor necrosis factor-α (TNF-α), interleukin (IL) 6, leptin, resistin, and adiponectin [1,2].