HK2 and neuroblastoma: Plasma cell tumor variant translocation 1 (PVT1) positively regulates the expression of HK II both in vivo and in vitro by suppressing miR-143 expression [62], and CircRNA-ACAP2 also impedes the invasive, migratory, and anti-apoptotic properties of neuroblastoma cells by targeting the miRNA-143-3-hexokinase 2 axis [63].