Fucoxanthin has been shown to act on the PI3K-AKT signaling pathway, thereby inducing cell cycle arrest and apoptosis and inhibiting proliferation, angiogenesis, and migration [66,67].Through the downregulation of PI3K/AKT/mTOR signaling, fucoxanthin has been proven to inhibit proliferation and stimulate apoptosis in ovarian cancer cells [68]. The gene discussed is PIK3CA; the disease is ovarian cancer.