PTGS2 and periodontitis: Currently, cyclooxygenase-2 (COX-2) inhibitors such as celecoxib and polmacoxib are fatal in cardiovascular and renal diseases, and these drugs only slow down the progression of periodontitis and are not known as a fundamental treatment method; in addition, NSAID anti-inflammatory analgesics are traditionally used to treat periodontitis, but they mainly inhibit the function of COX, which is induced by the transcriptional activity of NF-κB, and suppress only downstream signals of NF-κB [39].