Moreover, these authors showed that Astragalin or KETTTIVR partially reversed the gut microbiota alterations in colitis mice, mainly by increasing the potentially beneficial bacteria load (such as Ruminococcaceae) and decreasing the potentially harmful bacteria load (such as Escherichia-Shigella) [116], or by remodeling the intestinal mucosal barrier through inhibiting the JAK–STAT activation in colitis [117]. The gene discussed is SOAT1; the disease is colitis.