In our study using oligonucleotide microarrays, we found that the levels of MMP11, MMP14, MMP15, MMP24-A, and ADAMTS7 were significantly upregulated, while TIMP2 was downregulated in the PBMCs of AMD patients after receiving three injections of ranibizumab. The gene discussed is MMP15; the disease is age-related macular degeneration.