In a nutshell, protein components of the ribosome are encoded by a set of ~80 RPGs, half of which are bound by WDR5 in all cancer cell types profiled to date, including MLLr leukemia cells [16], Burkitt lymphoma cells [53], colorectal cancer cells [5], neuroblastoma cells [5], and rhabdoid tumor cells [62]. Here, WDR5 is linked to colorectal cancer.