It should be emphasised that the authors used specific experimental methods to avoid inducing HHT-like vascular malformations (using a novel antibody chosen specifically because it blocked LDL binding without affecting BMP signalling, and a Bmx Cre that they showed did not induce retinal or cerebral arteriovenous malformations) [125]. The gene discussed is BMX; the disease is arteriovenous malformations of the brain.