Comparably, studies by Khodadadi et al. (2020) found that administration of CBD downregulated levels of proinflammatory cytokines IL-6, IFN-γ, and TNF-α, reduced the number of infiltrating neutrophils and macrophages in the lungs, and improved clinical symptoms of Poly I:C-induced ARDS [36]. This evidence concerns the gene TNF and acute respiratory distress syndrome.