In the multivariate linear regression analysis for all CKD participants, age, diabetes, and serum albumin showed significant associations with both hands ESC (β in model 2: −0.40, −4.89, and 7.62, respectively; Table 3) and feet ESC (β in model 2: −0.38, −7.27, and 8.80, respectively; Table 3). The gene discussed is ALB; the disease is chronic kidney disease.