It is worth noting that while S100B offers higher specificity for melanoma compared to LDH, elevated S100B levels have been measured in various other conditions, including cardiovascular diseases, liver cirrhosis, migraine, breast carcinoma, vitiligo, SARS-CoV-2 infection, brain, liver, and kidney injury [20,23,24,25]. The gene discussed is S100B; the disease is cirrhosis of liver.