Supporting the involvement of IL-17 in EMT-dependent fibrosis, Sisto et al. recently demonstrated that IL-17, through the support of IL-22, contributes to triggering the EMT-dependent fibrotic process in healthy human salivary gland epithelial cells, clarifying the role of IL-17 in the fibrotic evolution observed in SS [53]. The gene discussed is IL17A; the disease is synovial sarcoma.