Desmoplakin (DSP) is the most common gene involved, accounting for 69% of cases, followed by plakophilin-2 (PKP-2), desmoglein-2 (DSG-2) desmin (DES), and the junction plakoglobin (JUP) gene, associated with Naxos disease; the mutation of other genes beyond desmosome has also been demonstrated to a lesser extent, like phospholamban (PLN), lamin A/C (LMNA), integrin-like kinase (ILK), titin (TTN) or genes encoding for area composita like cadherin-C (CDH-2) and alpha-T-catenin (CTNNA3). This evidence concerns the gene PKP2 and Naxos disease.