CNIH2 and gout: Notably, gout susceptibility loci, including genes such as ABCG2 and SLC2A9 (involved in urate transport), rs1260326 of GCKR (associated with glucose and lipid metabolism), rs2188380 of MYL2-CUX2 (linked to cholesterol and diabetes mellitus), and rs4073582 of CNIH-2 (regulating glutamate signaling), have been identified at the genome-wide significance level [49].