In patients with gout, the deposition and phagocytosis of monosodium urate crystals in tissues activate the NLRP3 inflammasome [44], leading to the production of critical cytokines such as IL-1β, IL-6, and tumor necrosis factor (TNF)-α [42,43], which are implicated in the occurrence of migraines [21]. This evidence concerns the gene NLRP3 and gout.